PGE1 Prostaglandin E1 Alprostadil Bulk powder

Pharmacology:

A wide variety of pharmacological effects of Alprostadil are vasodilation, inhibition of platelet aggregation, and stimulation of intestinal and uterine smooth muscle. Alprostadil induces erection by relaxation of trabecular smooth muscle and by dilation of cavernosal arteries.

In vitro, Alprostadil has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations.

In human studies using Doppler duplex ultrasonography, administration of Alprostadil resulted in an increase in peak systolic flow velocities.

Applications:

1. Cardiovascular disorders:
Maintaining the patency of the ductus arteriosus in neonates with congenital heart disease until surgery is possible².

2. Peripheral vascular disease:
Alprostadil can be administered by intra-arterial or intravenous infusion³.

3. Erectile Dysfunction:
Intracavernous injection⁴, intra-urethral application⁵and non-invasive delivery systems including topical and needle-less applications⁶.

Proprietary Names:

Befar^â, Caverject^â, Edex^â, Liple^â, Minprog^â, MUSE^â, Palus^â, Prostandin^â, Prostavasin^â, Prostin^âVR, Prostine^âVR, Prostivas^â, Sutine^â, Topiglan^®.